研究室の業績

・S. Uno, H. Tanaka, E. Kokushi, E. T. Bacolod, J. Koyama: Distributions of nitrated polycyclic aromatic hydrocarbons in the sediment of Osaka Bay, Japan. Marine Pollution Bulletin. In print.

・E. T. Bacolod, S. Uno, S. S. Villamor, J. Koyama: Oxidative stress and genotoxicity biomarker responses in tilapia (Oreochromis niloticus) exposed to environmental concentration of 1-nitropyrene. Marine Pollution Bulletin. In print.

・J. Koyama, S. Nigaya, A. Takenouchi, E. Kokushi, S. Uno: Bioaccumulation of environmental organotin compounds in translocated rock shell Thais clavigera in Kagoshima Bay. Fisheries Science. In print.

・S. Uno, E. Kokushi, M. Kawano, A.E. McElroy, J. Koyama: Toxic evaluations of sediments in Tokyo Bay, Japan, using Japanese medaka embryos. Environmental Science and Pollution Research. In print.

・M. Kawano, S. Uno, J. Koyama, E. Kokushi, A. McElroy: Effects of oxygenated polycyclic aromatic hydrocarbons on the early life stages of Japanese medaka. Environmental Science and Pollution Research. In print.

・J. Koyama, S. Uno, Y. Nagai, B. Anukorn: Early monitoring of spilled oil contamination in Rayong, Thailand. Japanese Journal of Environmental Toxicology. In print.

・E. Kokushi, A. Shintoyo, J. Koyama, S. Uno: Evaluation of 2,4-dichlorophenol exposure of Japanese medaka, Oryzias latipes, using a metabolomics approach. Environmental Science and Pollution Research. In print.

・M. Y. Nurulnadia, J. Koyama, S. Uno, H. Amano: Biomagnification of endocrine disrupting chemicals (EDCs) by Pleuronectes yokohamae: Does P. yokohamae accumulate dietary EDCs?, Chemosphere, 2016. 144. 185-192.

・河野真知、宇野誠一、國師恵美子、小山次朗: ゲンタマイシン腹腔内暴露により腎障害を誘発したコイの血漿中代謝物変動.環境毒性学会誌.2015. 18. 25-37.

・K Ito, S Uno, H Tanaka, S Miki, E Kokushi, M Yamamoto, J Koyama, N C Anasco: Distribution of parent and alkylated PAHs in bivalves collected from Osaka Bay, Japan. Japanese Journal of Environmental Toxicology. 2015.18. 11-24.

・Y. Fushimi, M. Takagi, D. Monniaux, S. Uno, E. Kokushi, U. Shinya, C. Kawashima, T. Otoi, E. Deguchi, J. Fink-Gremmels: Effects of dietary contamination by zearalenone and its metabolites on serum anti-müllerian hormone: impact on the reproductive performance of breeding cows. Reproduction in Domestic Animals. 2015. 50. 834-839.

・Y. Fushimi, M. Takagi, S. Uno, E. Kokushi, M. Nakamura, H. Hasunuma, U. Shinya, E. Deguchi, J. Fink-Gremmels: Measurement of sterigmatocystin concentrations in urine for monitoring the contamination of cattle feed. Toxins. 2014. 6. 3117-3128.

・S. N. Nuñal, L. Santander-de, M. S. Sheila, E. Bacolod, J. Koyama, S. Uno, M. Hidaka, T. Yoshikawa, H. Maeda: Bioremediation of heavily oil-polluted seawater by a bacterial consortium immobilized in cocopeat and rice hull powder. Biocontrol Science. 2014. 19. 11-22.

・J. Koyama, C. Imakado, S. Uno, T. Kuroda, S, Hara, T. Majima, H. Shirota, N. C. Añasco: Simulated distribution and ecotoxicity-based assessment of chemically-dispersed oil in Tokyo bay. Marine Pollution Bulletin. 2014. 85. 487-493.

・S. Miki, S. Uno, K. Ito, J. Koyama, H. Tanaka: Distributions of polycyclic aromatic hydrocarbons and alkylated polycyclic aromatic hydrocarbons in Osaka Bay, Japan. 2014. Marine Pollution Bulletin. 85. 558-565.

・M. Y. Nurulnadia, J. Koyama, S. Uno, A. Kito, E. Kokushi, E. T. Bacolod, K. Ito, Y. Chuman: Accumulation of endocrine disrupting chemicals (EDCs) in the polychaete Paraprionospio sp. from the Yodo River mouth, Osaka Bay, Japan. Environmental Monitoring and Assessment. 2014. 186. 1453-1463.

・Y. Fushimi, M. Takagi, H. Hasunuma, S. Uno, E. Kokushi, U. Watanabe, J. Liu, M. Marey, A. Miyamoto, T. Otoi, E. Deguchi, J. Fink-Gremmels. Application of mycotoxin adsorbent to cattle herd naturally contaminated with zearalenone: Urinary zearalenone excretion and association with anti-Mullerian hormone. World Mycotoxin J. 2014. 7. 367-378.

・S. Dasgupta, A. Cao, B. Mauer, B. Yan, S. Uno, A. McElroy: Genotoxicity of oxy-PAHs to Japanese medaka (Oryzias latipes) embryos assessed using the comet assay. Environmental Science and Pollution Research. 2014. 21. 13867-13876.

・T. B. Eugene, S. Uno, H. Tanaka, S. Miki, E. Kokushi, M. Fukunaga, J. Koyama: Bioconcentration of waterborne nitroarenes in marbled flounder Pleuronectes yokohamae. Japanese Journal of Environmental Toxicology. 2013. 16. 91-105.

・T. B. Eugene, S. Uno, H. Tanaka, J. Koyama: Micronuclei and nuclear abnormalities induction in erythrocytes of marbled flounder, Pleuronectes yokohamae, exposed to dietary nitrated polycyclic aromatic hydrocarbons. Japanese Journal of Environmental Toxicology. 2013. 16. 79-89.

・R. Sambuu, M. Takagi, Z. Namula, M. Nii, M. Taniguchi, S. Uno, E. Kokushi, C. Tshering, R. R. dos Santos, J. Fink-Gremmels, T. Otoi: Effects of long-term in vitro exposure of ejaculated boar sperm to zearalenone and α-zearalenol in sperm liquid storage medium. Animal Science Journal. 2013. 84. 28-34.

・E. Kokushi, S. Uno, S. Pal, J. Koyama: Effects of chlorpyrifos on the metabolome of the freshwater carp, Cyprinus Carpio. Environ. Toxicol. 2015. 30. 253-260.

・M. Y. Nurulnadia, J. Koyama, S. Uno, E. Kokushi, E. T. Bacolod, K. Ito, Y. Chuman: Bioaccumulation of dietary endocrine disrupting chemicals (EDCs) by the polychaete, Perinereis nuntia. Bulletin of Environmental Contamination and Toxicology. 2013. 91. 372-376.

・國師恵美子、宇野誠一、小山次朗:コイ血漿メタボロミクスによるカーバメート系殺虫剤BPMCの有害性評価.環境毒性学会誌.2013. 16. 1-11.

・M. Takagi, T. Hirai, S. Shiga, S. Uno, E. Kokushi, T. Otoi, E. Deguchi, C. Tshering: Relationship between urinary zearalenone concentration and embryo production in superovulated cattle. Archives Animal Breeding. 2013. 36. 360-366.

・M.Takagi, S. Shiga, S. Uno, E. Kokushi, T. Otoi, C. Tshering, E. Deguchi, J. Fink-Gremmels: Periodic alteration in urinary zearalenone excretion in a dairy cattle herd. Animal Nutrition and Feed Technology. 2013, 13. 303-310.

・J. Koyama, A. Kitoh, M. Nakai, K. Kohno, H. Tanaka, S. Uno: Relative contribution of endocrine-disrupting chemicals to the estrogenic potency of marine sediments of Osaka bay, Japan. Water, Air & Soil Pollution. 2013. 224. 1570-1579.

・J. Koyama, A. Takenouchi, S. Nigaya, E. Kokushi, S. Uno: Organotin residues in Rock Shell, Thais clavigera, and their sources in Kagoshima Bay, Japan. Aquatic Ecosystem Health & Management. 2012. 15. 260-266.

・S. Uno, A. Shintoyo, E. Kokushi, M. Yamamoto, K. Nakayama, J. Koyama.: Gas chromatography-mass spectrometry for metabolite profiling of Japanese medaka (Oryzias latipes) juveniles exposed to malathion. Environmental Science and Pollution Research. 2012. 19: 2595–2605.

・H. Hasunuma, M. Takagi, O. Kawamura, C. Taniguchi, M. Nakamura, T. Chuma, S. Uno, E. Kokushi, D. Matsumoto, C. Tshering, E. Deguchi, J. Fink-Gremmels: Natural contamination of dietary rice straw with zearalenone and urinary zearalenone concentrations in a cattle herd. Jounal of Animal Science. 2012. 90. 1610-1616.

・J. Song, K. Nakayama, E. Kokushi, K. Ito, S. Uno, J. Koyama, H. Rahman, Y. Murakami, S. Kitamura: Effect of heavy oil exposure on antibacterial activity and expression of immune-related genes in Japanese flounder Paralichthys olivaceus. Environmental Toxicology and Chemistry. 2012. 31. 828-835.

・E. Kokushi, S. Uno, T. Harada, J. Koyama: 1H-NMR based metabolomics approach to assess toxicity of bunker A heavy oil to freshwater carp, Cyprinus carpio. Environ. Toxicol. 2012. 27. 404-414.

・S. Pal, E. Kokushi, J. Koyama, S. Uno, A. R. Ghosh: Histopathological alterations in gill, liver and kidney of common carp exposed to chlorpyrifos. Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. 2012. 47. 180-195.

・S. Uno, H. Tanaka, S. Miki, E. Kokushi, K. Ito, M. Yamamoto, J. Koyama: Bioaccumulation of nitroarenes in bivalves at Osaka Bay, Japan. Marine Pollution Bulletin. 2011. 63. 477-481.

・S. Pal, E. Kokushi, J. O. Cheikyula, J. Koyama, S. Uno: Histopathological effects and EROD induction in common carp exposed to dietary heavy oil. Ecotoxicology and Environmental Safety. 2011. 74. 307-314.

・H. Hasunuma, M. Takagi, S. Shiga, S. Uno, E. Kokushi, S. Mukai, T. Kuriyagawa, K. Takagaki, D. Matsumoto, K. Okamoto, E. Deguchi, J. Fink-Gremmels: Monitoring natural feed contamination in beef cattle by measurements of urinary zearalenone concentrations after oral administration of mycotoxin adsorbents as a top dressing. Journal of Applied Animal Research. 2011. 39. 292-295.

・H. M. Monteclaro, K. Anraku, S. Uno, J. Koyama, T. Matsuoka, H. Y. Yan: Sensitivity of crayfish antennules to hydrodynamic stimuli is reduced during diazinon exposure. Zoological Studies. 2011. 50. 145-154.
・R. Sambuu, M. Takagi, S. Shiga, S. Uno, E. Kokushi, Z. Namula, T. Otoi, A. Miyamoto, E. Deguchi, J. Fink-Gremmels: Detection of zearalenone and its metabolites in naturally contaminated porcine follicular fluid by using liquid chromatography tandem mass spectrometry. Journal of Reproduction and Development. 2011. 57. 303-306.

・M. Takagi, S. Uno, E. Kokushi, S. Shiga, S. Mukai, T. Kuriyagawa, K. Takagaki, H. Hasunuma, D. Matsumoto, K. Okamoto, F. Shahada, T. Chenga, E. Deguchi, and J. Fink-Gremmels: Measurement of urinary zearalenone concentrations for monitoring natural feed contamination in cattle herds – on-farm trials. Journal of Animal Science. 2011. 89. 287-296.

・國師恵美子、宇野誠一、小山次朗: 1H-NMRメタボローム解析を用いた絶食下コイCyprinus carpio L. の血漿中代謝物変動評価.日本水産学会誌.2011. 77. 75-83.

・S. Miki, J. Koyama, S. Uno: Optimization of pressurized liquid extraction for simultaneous analysis of polycyclic aromatic hydrocarbons and alkylated polycyclic aromatic hydrocarbons in sediments. Fresenius Environmental Bulletin. 2010. 19. 1544-1551.

・S. Uno, M. Murakami, E. Kokushi, J. Koyama: Inter-Species Differences in the Accumulation of tributyltin and its metabolites under dietary exposure in sea perch, Lateolabrax japonicus, and red sea bream, Pagrus major. Environmental Toxicology. 2011. 26. 29-36.

・S. Uno, J. Koyama, E. Kokushi, H. Monteclaro, S. Santander, J. O. Cheikyula, S. Miki, N. Añasco, I. G. Pahila, H. S. Taberna Jr., T. Matsuoka: Monitoring of PAHs and alkylated PAHs in aquatic organisms after one month from Solar I oil spill off the coast of Guimaras Island, Philippines. Environmental Monitoring and Assessment. 2010. 165. 501-515.

・N. C. Añasco, J. Koyama, S. Uno: Pesticide residues in coastal waters affected by rice paddy effluents temporarily stored in a wastewater reservoir in southern Japan. Archives of Environmental Contamination and Toxicology. 2010. 58. 352-360.

・N. Añasco, S. Uno, J. Koyama, T. Matsuoka, N. Kuwahara. Assessment of pesticide residues in freshwater areas affected by rice paddy effluents in southern Japan. Environmental Monitoring and Assessment. 2010. 160. 371-383

・J. Koyama, M. Murakami, S. Uno: Immunotoxicity of tributyl tin to Japanese sea bass, Lateolabrax japonicus and red sea bream, Pagrus major, in relation to their body burden. Japanese Journal of Environmental Toxicology. 2009. 12. 123-133.

・J. O. Cheikyula, J. Koyama, S. Uno: Micronuclei and other nuclear abnormalities formation in the red sea bream, Pagrus major, exposed to polycyclic aromatic hydrocarbons. Japanese Journal of Environmental Toxicology. 2009. 12. 33-39.

・M. Takagi, S. Mukai, T. Kuriyagawa, K. Takagaki, S. Uno, E. Kokushi, T. Otoi, A. Budiyanto, K. Shirasuna, A. Miyamoto, O. Kawamura, K. Okamoto, E. Deguchi: Detection of zearalenone and its metabolites in naturally contaminated follicularfluids by using LC/MS/MS and in vitro effects of zearalenone on oocyte maturation in cattle, Reproductive Toxicology. 2008. 26. 164–169.

・宇野誠一、國師恵美子、小山次朗:魚類血漿を用いた有害化学物質の1H-NMRメタボロミクス影響評価、環境毒性学会誌.2008. 11. 63-67.

・J. O. Cheikyula, J. Koyama, S. Uno: Bioaccumulation of dietary polycyclic aromatic hydrocarbons and EROD induction in the red sea bream and Java medaka. Japanese Journal of Environmental Toxicology. 2008.11. 99-115.

・J. Koyama, M. Kawamata, S. Imai, M. Fukunaga, S. Uno, A. Kakuno: Java medaka: a proposed new marine test fish for ecotoxicology. Environmental Toxicology. 2008. 23. 487-491.

・J. O. Cheikyula, J. Koyama, S. Uno: Comparative study of bioconcentration and EROD activity induction in the Japanese flounder, red sea bream, and Java medaka exposed to polycyclic aromatic hydrocarbons. Environmental Toxicology. 2008. 23. 354-362.

・J. Koyama, S. Uno, K. Kohno: Polycyclic aromatic hydrocarbon contamination and recovery characteristics in some organisms after the Nakhodka oil spill. Marine Pollution Bulletin. 2004. 49. 1054-1061.

・Y. Okumura, J. Koyama, S. Uno: The relationship between logPow and molecular weight of polycyclic aromatic hydrocarbons and EC50 values of marine microalgae. La mer. 2003. 41. 182-191.

・S. Uno, J. Koyama, K. Ikeda: Polycyclic aromatic hydrocarbons in liver and their metabolites in bile of founder (Paralichthys oivevaceus) orally exposed to crude oil and heavy fuel oil. Japanese Journal of Environmental Toxicology. 2003. 6. 53-64.

・T. Horiguchi, Z. Li, S. Uno, M. Shimizu, H. Shiraishi, M. Morita, J.A.J. Thompson, C.D. Levings: Contamination of organotin compounds and imposex in mollusks from Vancouver, Canada. Marine Environmental Research. 2003. 57. 75-88.

・宇野誠一、小山次朗、田中博之、山田久、白石寛明:超臨界抽出法を用いた魚介類中の有機塩素系農薬の分析.環境化学会誌.2003. 13. 427-434.

・S. Uno, H. Shiraishi, S. Hatakeyama, A. Otsuki, J. Koyama: Accumulative characteristics of pesticide residues in organs of bivalves (Anodonta Woodiana and Corbicula leana) under natural conditions. Archives of Environmental Contamination and Toxicology. 2001. 40. 35-47.

・S. Hatakeyama, H. Shiraishi, S. Uno: Overall pesticide effects on growth and emergence of two species of Ephemeroptera in a model stream carrying pesticide-polluted river water. Ecotoxicology. 1997. 6. 167-180.

・S. Uno, H. Shiraishi, S. Hatakeyama, A. Otsuki: Uptake and depuration kinetics and BCFs several pesticides in three species of shellfish (Corbicula leana, Corbicula Japonica, and Cipangopludina chinensis): Comparison between field and laboratory experiment. Aquatic Toxicology. 1997. 39. 23-43.

小山次朗先生の業績

・C. K. Yap, A. Ismail, J. Koyama, S. G. Tan: A preliminary study on the concentrations of CU and ZN in Java medaka Oryzias javanicus and sediments collected from some estuaries in the West coast of Peninsular Malaysia. Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper. 2009. 11. 241-246.

・N. C. Añasco, J. Koyama, S. Imai, K. Nakamura: Toxicity of residual chlorines from hypochlorite-treated seawater to marine amphipod Hyale barbicornis and estuarine fish Oryzias javanicus. Water, Air and Soil Pollution. 2008. 195. 129-136.

・S. Imai, J. Koyama, K. Fujii: Effects of estrone on full life-cycle of Java medaka, a new marine test fish. Environmental Toxicology and Chemistry. 2007. 26. 726-731.

・J. Koyama, S. Imai, K. Fujii, S. Kawai, C. K. Yap, A. Ismail: Pollution by estrogens in river and estuarine waters around Kuala Lumpur, Malaysia, and their effects on the estuarine Java-medaka, Oryzias javanicus. Japanese Journal of Environmental Toxicology. 2006. 9. 141-148.

・S. Imai, J. Koyama, K. Fujii: Effects of 17b-estradiol on reproduction of Java-medaka (Oryzias javanicus), a new test fish. Marine Pollution Bulletin. 2005. 51. 708-714.

・Y. Oshima, J. Koyama, K. Nakayama, Y. Inoue, Y. Shimasaki, S. Inoue, T. Honjo: Use of hepatic CYP1A1 activity in Japanese flounder to monitor oil dispersed from the Nakhodka spill. Japanese Journal of Environmental Toxicology. 2004. 7. 123-129.

・角埜彰・小山次朗:マダイの血液性状を指標とした汚染物質の影響評価、環境毒性学会誌.2004. 7. 81-95.

・J. Koyama, A. Kakuno: Toxicity of heavy fuel oil, dispersant, and oil-dispersant mixtures to a marine fish, Pagrus major. Fisheries Science. 2004. 70. 587-594.